Critical Path Institute

Accelerating Drug Development, Transforming Lives

At Critical Path Institute (C-Path), we lead groundbreaking collaborations that accelerate drug development, bringing better treatments to people worldwide. By uniting experts from across the biomedical ecosystem, we shape innovative scientific and regulatory pathways to ensure therapies reach those in need—faster and more efficiently.

The journey from scientific discovery to an approved treatment is long, costly, and complex. C-Path breaks down these barriers by forming collaborative workgroups that identify challenges in drug development and create actionable tools and solutions to overcome them.

Our Impact

C-Path’s work has contributed to:

✅ The first new treatment and regimen for tuberculosis in over 50 years

✅ The first imaging biomarker for polycystic kidney disease, supporting the approval of the first-ever therapy to slow disease progression

✅ The first computerized tool to optimize Alzheimer’s clinical trial design, endorsed by the FDA and EMA

✅ Patient-centered outcome assessments that improve treatment evaluation for asthma, depression, irritable bowel syndrome, myelofibrosis, and lung cancer

✅ Regulatory-endorsed biomarkers for Alzheimer’s, Parkinson’s, type 1 diabetes, kidney disease, and tuberculosis

Rooted in Arizona, Driving Global Change

Founded in Tucson, Arizona, C-Path’s success is fueled by visionary support from the FDA, University of Arizona, Science Foundation Arizona, Flinn Foundation, and local businesses and individuals who believe in our mission.

Why It Matters

"CPAD's data collection efforts have produced the best data source in the world for predictive modeling and understanding how patient and trial design impact Alzheimer’s drug development. This work helps us all conduct better, more efficient clinical trials."— Lars Lau Raket, Novo Nordisk

"This matters. Part of the reason why I have a kidney is to be able to live my life, and I want to be able to live it."— Haley Jensen, Transplant Recipient and Advocate

Join us in advancing life-changing treatments. Your support fuels innovation, collaboration, and hope.

Donate today.