Native American Advancement Foundation (NAAF) has responded to diverse needs caused by COVID-19 on the Tohono O'odham Nation reservation. Since March 2020, we provide remote education resources for preK-12th grade students and adult learners; daily meal delivery to children; food and basic human needs for GuVo District families and elders. NAAF continues our community-based work in education, prevention services, and Tohono O'odham culture and language, while we mitigate the detrimental impacts of COVID-19 in food insecurity, public health, economic hardship, education and technology access in this remote area in Southern Arizona.